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Details about AstraZeneca vaccine (Vaxzevria)



NEWS: Starting from the 1st of April, between the doses intervals may be extended – the current interval between the doses is from 84 to 91 days. The information mentioned below are in compliance with the methodology adopted before new rules come into the force – methodology update is currently in progress.

Vaxzevria (by AstraZeneca) has been wildly discussed mainly due to the ability to protect older people. However, any research study has not proved vaccine inefficiency in the elder people cohort.

VACCINE EFFICACY IN OVER 65 COHORT

European Medicines Agency (EMA) has been requesting to include at least 25 % of the over 65 population into the research studies of efficacy.  AstraZeneca included only 6 %. Because of not observing this criterion, this fact about lack of the data for the cohort is stated commonly. Nevertheless, based on the experience with other vaccines, Vaxzevria is expected to at least partly protect elder people cohort – the level of protection is a subject of discussions. Research studies examining the protection for elder people cohort are still in progress. Current results show that immunogenicity (ability to induce antibodies and cellular immune response) is not significantly different.

Newspaper articles are the reaction mostly on the lack of the data itself, not as the reaction on the data that would prove vaccine inefficacy in the discussed cohort.

ADDITIONAL INFORMATION ABOUT VAXZEVRIA

Current research studies have been dealing only with individuals 18 years and older. Youths are not recommended to get this vaccine until the valid research data will be released.

The vaccination schedule consists of two separate doses. The second dose is scheduled between the 4th and 12th week after getting the first dose. The latest data shows that longer interval between the doses increases the quality of protection. Partial protection is formed approximately after 3 weeks from the first doses, complete protection is expected 2 weeks after the second dose.